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1

A series of 5-aminosubstituted 4-fluorobenzyl-8-hydroxy-[1,6]naphthyridine-7-carboxamide HIV-1 integrase inhibitors

James P. Guare, John S. Wai, Robert P. Gomez, Neville J. Anthony, Samson M. Jolly, Amanda R. Cortes, Joseph P. Vacca, Peter J. Felock, Kara A. Stillmock, William A. Schleif, Gregory Moyer, Lori J. Gab

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2006

Language:

english

File:

PDF, 159 KB

english, 2006

2

Design and synthesis of HIV protease inhibitors. Variations of the carboxyterminus of the HIV protease inhibitor L-682,679

DeSolms, S. Jane, Giuliani, Elizabeth A., Guare, James P., Vacca, Joseph P., Sanders, William M., Graham, Samuel L., Wiggins, J. Mark, Darke, Paul L., Sigal, Irving S.

Journal:

Journal of Medicinal Chemistry

Year:

1991

Language:

english

File:

PDF, 772 KB

english, 1991

3

The hot emission-line objects in IRAS 17380-3031 and 18405-0448

Williams, P. M., Cohen, M., van der Hucht, K. A., Bouchet, P., Vacca, W. D.

Journal:

Monthly Notices of the Royal Astronomical Society

Year:

1995

File:

PDF, 188 KB

1995

4

DIRECT SPECTROSCOPIC IDENTIFICATION OF THE ORIGIN OF “GREEN FUZZY” EMISSION IN STAR-FORMING REGIONS

De Buizer, James M., Vacca, William D.

Journal:

The Astronomical Journal

Year:

2010

Language:

english

File:

PDF, 1.37 MB

english, 2010

5

THE UNUSUAL OBJECT IC 2144/MWC 778

Herbig, G. H., Vacca, William D.

Journal:

The Astronomical Journal

Year:

2008

Language:

english

File:

PDF, 307 KB

english, 2008

6

SPECTRAL CLASSIFICATION OF THE BRIGHTEST OBJECTS IN THE GALACTIC STAR-FORMING REGION W40

Shuping, R. Y., Vacca, William D., Kassis, Marc, Yu, Ka Chun

Journal:

The Astronomical Journal

Year:

2012

Language:

english

File:

PDF, 76 KB

english, 2012

7

EVIDENCE FOR AN EDGE-ON DISK AROUND THE YOUNG STAR MWC 778 FROM INFRARED IMAGING AND POLARIMETRY

Perrin, Marshall D., Vacca, William D., Graham, James R.

Journal:

The Astronomical Journal

Year:

2009

Language:

english

File:

PDF, 538 KB

english, 2009

8

TIMP-2 over-expression reduces invasion and angiogenesis and protects B16F10 melanoma cells from apoptosis

Piera Valente, Gianfranco Fassina, Antonella Melchiori, Luciana Masiello, Michele Cilli, Angelo Vacca, Maurizio Onisto, Leonardo Santi, William G. Stetler-Stevenson, Adriana Albini

Journal:

International Journal of Cancer

Year:

1998

Language:

english

File:

PDF, 569 KB

english, 1998

9

The Near Infrared Spectrum of Miranda: Evidence of Crystalline Water Ice

James M. Bauer, Ted L. Roush, Thomas R. Geballe, Karen J. Meech, Tobias C. Owen, William D. Vacca, John T. Rayner, Kevin T.C. Jim

Journal:

Year:

2002

Language:

english

File:

PDF, 387 KB

english, 2002

10

A new hydroxyethylamine class of HIV-1 protease inhibitors with high antiviral potency and oral bioavailability

B.Moon Kim, Joseph P. Vacca, James P. Guare, Colleen M. Hanifin, Stuart R. Michelson, PaulL. Darke, Joan A. Zugay, Emilio A. Emini, William Schleif, Jiunn H. Lin, I-Wu Chen, Kari Vastag, Drazen Ostovi

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1994

Language:

english

File:

PDF, 463 KB

english, 1994

11

Thiophene derivatives as extremely high affinity P3′ ligands for the hydroxyethylpiperazine class of HIV-1 protease inhibitors

B. Moon Kim, James P. Guare, Joseph D. Vacca, Stuart R. Michelson, Paul L. Darke, Joan A. Zugay, Emilio A. Emini, William Schleif, Jiunn H. Lin, I.W. Chen, Kari Vastag, Paul S. Anderson, Joel R. Huff

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1995

Language:

english

File:

PDF, 297 KB

english, 1995

12

Substituted alkylpyridines as P3′ ligands for the hydroxyethylpiperazine class of HIV-1 protease inhibitors: Improved pharmacokinetic profiles

B. Moon Kim, Colleen M. Hanifin, C. Blair Zartman, Joseph P. Vacca, Stuart R. Michelson, Jiunn H. Lin, I.-W. Chen, Kari Vastag, Paul L. Darke, Joan A. Zugay, Emilio A. Emini, William Schleif, Paul S.

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1995

Language:

english

File:

PDF, 277 KB

english, 1995

13

Cycloalkylpiperazines as HIV-1 protease inhibitors: enhanced oral absorption

B. Moon Kim, Ben E. Evans, Kevin F. Gilbert, Colleen M. Hanifin, Joseph P. Vacca, Stuart R. Michelson, Paul L. Darke, Joan A. Zugay, Emilio A. Emini, William Schleif, Jiunn H. Lin, I.-W. Chen, Kari Va

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1995

Language:

english

File:

PDF, 287 KB

english, 1995

14

Low molecular weight thrombin inhibitors with excellent potency, metabolic stability, and oral bioavailability

Matthew M Morrissette, Kenneth J Stauffer, Peter D Williams, Terry A Lyle, Joseph P Vacca, Julie A Krueger, S.Dale Lewis, Bobby J Lucas, Bradley K Wong, Rebecca B White, Cynthia Miller-Stein, Elizabet

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2004

Language:

english

File:

PDF, 283 KB

english, 2004

15

Dihydroxypyridopyrazine-1,6-dione HIV-1 integrase inhibitors

John S. Wai, Boyoung Kim, Thorsten E. Fisher, Linghang Zhuang, Mark W. Embrey, Peter D. Williams, Donnette D. Staas, Chris Culberson, Terry A. Lyle, Joseph P. Vacca, Daria J. Hazuda, Peter J. Felock,

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2007

Language:

english

File:

PDF, 226 KB

english, 2007

16

8-Hydroxy-3,4-dihydropyrrolo[1,2-a]pyrazine-1(2H)-one HIV-1 integrase inhibitors

Thorsten E. Fisher, Boyoung Kim, Donnette D. Staas, Terry A. Lyle, Steven D. Young, Joseph P. Vacca, Matthew M. Zrada, Daria J. Hazuda, Peter J. Felock, William A. Schleif, Lori J. Gabryelski, M. Reza

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2007

Language:

english

File:

PDF, 143 KB

english, 2007

17

Design and synthesis of substituted 4-oxo-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrazine-2-carboxamides, novel HIV-1 integrase inhibitors

H. Marie Langford, Peter D. Williams, Carl F. Homnick, Joseph P. Vacca, Peter J. Felock, Kara A. Stillmock, Marc V. Witmer, Daria J. Hazuda, Lori J. Gabryelski, William A. Schleif

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2008

Language:

english

File:

PDF, 140 KB

english, 2008

18

10-Hydroxy-7,8-dihydropyrazino[1′,2′:1,5]pyrrolo[2,3-d]pyridazine-1,9(2H,6H)-diones: Potent, orally bioavailable HIV-1 integrase strand-transfer inhibitors with activity against integrase mutants

Catherine M. Wiscount, Peter D. Williams, Lekhanh O. Tran, Mark W. Embrey, Thorsten E. Fisher, Vanessa Sherman, Carl F. Homnick, D. Donnette Staas, Terry A. Lyle, John S. Wai, Joseph P. Vacca, ZiQiang

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2008

Language:

english

File:

PDF, 164 KB

english, 2008

19

Synthesis of 5-(1-H or 1-alkyl-5-oxopyrrolidin-3-yl)-8-hydroxy-[1,6]-naphthyridine-7-carboxamide inhibitors of HIV-1 integrase

Jeffrey Y. Melamed, Melissa S. Egbertson, Sandor Varga, Joseph P. Vacca, Greg Moyer, Lori Gabryelski, Peter J. Felock, Kara A. Stillmock, Marc V. Witmer, William Schleif, Daria J. Hazuda, Yvonne Leona

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2008

Language:

english

File:

PDF, 202 KB

english, 2008

20

Optimization of azepanone calcitonin gene-related peptide (CGRP) receptor antagonists: Development of novel spiropiperidines

Christopher S. Burgey, Craig M. Potteiger, James Z. Deng, Scott D. Mosser, Christopher A. Salvatore, Sean Yu, Shane Roller, Stefanie A. Kane, Joseph P. Vacca, Theresa M. Williams

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2009

Language:

english

File:

PDF, 707 KB

english, 2009

21

Epsilon substituted lysinol derivatives as HIV-1 protease inhibitors

Kristen L.G. Jones, M. Katharine Holloway, Hua-Poo Su, Steven S. Carroll, Christine Burlein, Sinoeun Touch, Daniel J. DiStefano, Rosa I. Sanchez, Theresa M. Williams, Joseph P. Vacca, Craig A. Coburn

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2010

Language:

english

File:

PDF, 714 KB

english, 2010

22

Potent and selective HIV-1 ribonuclease H inhibitors based on a 1-hydroxy-1,8-naphthyridin-2(1H)-one scaffold

Peter D. Williams, Donnette D. Staas, Shankar Venkatraman, H. Marie Loughran, Rowena D. Ruzek, Theresa M. Booth, Terry A. Lyle, John S. Wai, Joseph P. Vacca, Bradley P. Feuston, Linda T. Ecto, Jessica

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2010

Language:

english

File:

PDF, 320 KB

english, 2010

23

Synthesis and evaluation of pyridyl analogs of L-735,524: Potent HIV-1 protease inhibitors

Bruce D. Dorsey, Stacey L. McDaniel, Rhonda B. Levin, Joseph P. Vacca, Paul L. Darke, Joan A. Zuga, Emilio A. Emini, William A. Schleif, Jiunn H. Lin, I-W. Chen, M.Katharine Holloway, Paul S. Anderson

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1994

Language:

english

File:

PDF, 406 KB

english, 1994

24

Identification and SAR for a selective, nonpeptidyl thrombin inhibitor

Adel M. Naylor-Olsen, Gerald S. Ponticello, S.Dale Lewis, Anne M. Mulichak, Zhonguo Chen, Charles N. Habecker, Brian T. Phillips, William M. Sanders, Thomas J. Tucker, Jules A. Shafer, Joseph P. Vacca

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1998

Language:

english

File:

PDF, 382 KB

english, 1998

25

The formation and evolution of massive stellar clusters in IC4662

Andrea M. Gilbert, William D. Vacca

Journal:

Astrophysics and Space Science

Year:

2009

Language:

english

File:

PDF, 696 KB

english, 2009

26

The influence of mutanase and dextranase on the production and structure of glucans synthesized by streptococcal glucosyltransferases

Mitsue F Hayacibara, Hyun Koo, Anne M Vacca Smith, Leslie K Kopec, Kathleen Scott-Anne, Jaime A Cury, William H Bowen

Journal:

Carbohydrate Research

Year:

2004

Language:

english

File:

PDF, 318 KB

english, 2004

27

Responses of a beaded Arctic stream to short-term N and P fertilisation

JONATHAN P. BENSTEAD, LINDA A. DEEGAN, BRUCE J. PETERSON, ALEXANDER D. HURYN, WILLIAM B. BOWDEN, KELLER SUBERKROPP, KAREN M. BUZBY, ADRIAN C. GREEN, JAY A. VACCA

Journal:

Freshwater Biology

Year:

2005

Language:

english

File:

PDF, 297 KB

english, 2005

28

Pancreatic function in cirrhosis of the liver

Guy E. Van Goidsenhoven, Wilbert J. Henke, Joseph B. Vacca, William A. Knight

Journal:

Digestive Diseases and Sciences

Year:

1963

Language:

english

File:

PDF, 778 KB

english, 1963

29

Identification of a novel RAMP-independent CGRP receptor antagonist

C. Blair Zartman, Ian M. Bell, Steven N. Gallicchio, Samuel L. Graham, Stefanie A. Kane, John J. Mallee, Ruth Z. Rutledge, Christopher A. Salvatore, Joseph P. Vacca, Theresa M. Williams

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2011

Language:

english

File:

PDF, 500 KB

english, 2011

30

Design and synthesis of pyridone inhibitors of non-nucleoside reverse transcriptase

Robert Gomez, Samson Jolly, Theresa Williams, Thomas Tucker, Robert Tynebor, Joe Vacca, Georgia McGaughey, Ming-Tain Lai, Peter Felock, Vandna Munshi, Daniel DeStefano, Sinoeun Touch, Mike Miller, You

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2011

Language:

english

File:

PDF, 1.02 MB

english, 2011

31

Design of Novel, Potent, Noncovalent Inhibitors of Thrombin with Nonbasic P-1 Substructures: Rapid Structure−Activity Studies by Solid-Phase Synthesis

Lumma,, William C., Witherup, Keith M., Tucker, Thomas J., Brady, Steven F., Sisko, John T., Naylor-Olsen, Adel M., Lewis, S. Dale, Lucas, Bobby J., Vacca, Joseph P.

Journal:

Journal of Medicinal Chemistry

Year:

1998

Language:

english

File:

PDF, 83 KB

english, 1998

32

Clinical evaluation of acetyl-digitoxin

Joseph B. Vacca, Joseph M. Schuster, William A. Knight Jr.

Journal:

The American Journal of Cardiology

Year:

1958

Language:

english

File:

PDF, 569 KB

english, 1958

33

Design and Synthesis of Conformationally Constrained Inhibitors of Non-Nucleoside Reverse Transcriptase

Gomez, Robert, Jolly, Samson J., Williams, Theresa, Vacca, Joseph P., Torrent, Maricel, McGaughey, Georgia, Lai, Ming-Tain, Felock, Peter, Munshi, Vandna, DiStefano, Daniel, Flynn, Jessica, Miller, Mi

Journal:

Journal of Medicinal Chemistry

Year:

2011

Language:

english

File:

PDF, 2.57 MB

english, 2011

34

L-735,524: The Design of a Potent and Orally Bioavailable HIV Protease Inhibitor

Dorsey, Bruce D., Levin, Rhonda B., McDaniel, Stacy L., Vacca, Joseph P., Guare, James P., Darke, Paul L., Zugay, Joan A., Emini, Emilio A., Schleif, William A.

Journal:

Journal of Medicinal Chemistry

Year:

1994

Language:

english

File:

PDF, 2.17 MB

english, 1994

35

N-(1,3,4,6,7,12b-hexahydro-2H-benzo[b]furo[2,3-a]quinolizin-2-yl)-N-methyl-2-hydroxyethanesulfonamide: a potent and selective .alpha.2-adrenoceptor antagonist

Huff, Joel R., Anderson, Paul S., Baldwin, John J., Clineschmidt, Bradley V., Guare, James P., Lotti, Victor J., Pettibone, Douglas J., Randall, William C., Vacca, Joseph P.

Journal:

Journal of Medicinal Chemistry

Year:

1985

Language:

english

File:

PDF, 542 KB

english, 1985

36

Synthesis of the (3 R ,6 S )-3-Amino-6-(2,3-difluorophenyl)azepan-2-one of Telcagepant (MK-0974), a Calcitonin Gene-Related Peptide Receptor Antagonist for the Treatment of Migraine Headache

Burgey, Christopher S., Paone, Daniel V., Shaw, Anthony W., Deng, James Z., Nguyen, Diem N., Potteiger, Craig M., Graham, Samuel L., Vacca, Joseph P., Williams, Theresa M.

Journal:

Organic Letters

Year:

2008

Language:

english

File:

PDF, 127 KB

english, 2008

37

A Method of Correcting Near‐Infrared Spectra for Telluric Absorption

Vacca, William D., Cushing, Michael C., Rayner, John T.

Journal:

Publications of the Astronomical Society of the Pacific

Year:

2003

Language:

english

File:

PDF, 1.52 MB

english, 2003

38

Nonlinearity Corrections and Statistical Uncertainties Associated with Near‐Infrared Arrays

Vacca, William D., Cushing, Michael C., Rayner, John T.

Journal:

Publications of the Astronomical Society of the Pacific

Year:

2004

Language:

english

File:

PDF, 254 KB

english, 2004

39

Spextool: A Spectral Extraction Package for SpeX, a 0.8–5.5 Micron Cross‐Dispersed Spectrograph

Cushing, Michael C., Vacca, William D., Rayner, John T.

Journal:

Publications of the Astronomical Society of the Pacific

Year:

2004

Language:

english

File:

PDF, 683 KB

english, 2004

40

Interchange

John William Logan, Jo Anne Vacca, David Dickey and Judy Turner

Journal:

The Reading Teacher

Year:

1978

Language:

english

File:

PDF, 791 KB

english, 1978

41

Structure-affinity relationships of arylquinolizines at .alpha.-adrenoceptors

Huff, Joel R., Baldwin, John J., DeSolms, S. Jane, Guare, James P., Hunt, Cecilia A., Randall, William C., Sanders, William S., Smith, Steven J., Vacca, Joseph P., Zrada, Matthew M.

Journal:

Journal of Medicinal Chemistry

Year:

1988

Language:

english

File:

PDF, 658 KB

english, 1988

42

Toward a corroborative framework of indicators of reading comprehension

Page, William D., Vacca, Richard T.

Journal:

Year:

1980

Language:

english

File:

PDF, 468 KB

english, 1980

43

Flail chest

Poirier, William J., Vacca, Vincent M.

Journal:

Nursing Critical Care

Year:

2014

Language:

english

File:

PDF, 133 KB

english, 2014

44

Flail chest

Poirier, William J., Vacca, Vincent M.

Journal:

Nursing (Ed. española)

Year:

2013

Language:

english

File:

PDF, 226 KB

english, 2013

45

Structural aspects of glucans formed in solution and on the surface of hydroxyapatite

Kopec, Leslie K., Vacca-Smith, Anne M., Bowen, William H.

Journal:

Year:

1997

Language:

english

File:

PDF, 659 KB

english, 1997

46

HERSCHEL /PACS SURVEY OF PROTOPLANETARY DISKS IN TAURUS/AURIGA—OBSERVATIONS OF [O I] AND [C II], AND FAR-INFRARED CONTINUUM

Howard, Christian D., Sandell, Göran, Vacca, William D., Duchêne, Gaspard, Mathews, Geoffrey, Augereau, Jean-Charles, Barrado, David, Dent, William R. F., Eiroa, Carlos, Grady, Carol, Kamp, Inga, Meeu

Journal:

The Astrophysical Journal

Year:

2013

Language:

english

File:

PDF, 197 KB

english, 2013

47

OBSERVATIONS OF TYPE Ia SUPERNOVA 2014J WITH FLITECAM ON SOFIA

Vacca, William D., Hamilton, Ryan T., Savage, Maureen, Shenoy, Sachindev, Becklin, E. E., McLean, Ian S., Logsdon, Sarah E., Marion, G. H., Ashok, N. M., Banerjee, D. P. K., Evans, A., Fox, O. D., Gar

Journal:

The Astrophysical Journal

Year:

2015

Language:

english

File:

PDF, 849 KB

english, 2015

48

The Rise Times and Bolometric Light Curve of SN 1994D: Constraints on Models of Type Ia Supernovae

Vacca, William D., Leibundgut, Bruno

Journal:

The Astrophysical Journal

Year:

1996

Language:

english

File:

PDF, 2.17 MB

english, 1996

49

Effects of Apis mellifera Propolis on the Activities of Streptococcal Glucosyltransferases in Solution and Adsorbed onto Saliva–Coated Hydroxyapatite

Koo, Hyun, Vacca Smith, Anne M., Bowen, William H., Rosalen, Pedro L., Cury, Jaime A., Park, Yong K.

Journal:

Caries Research

Year:

2000

Language:

english

File:

PDF, 279 KB

english, 2000

50

Synthesis of Telcagepant (MK-0974)

C. Burgey, D. Paone, A. Shaw, J. Deng, D. Nguyen, C. Potteiger, S. Graham, J. Vacca, T. Williams

Year:

2009

Language:

english

File:

PDF, 70 KB

english, 2009

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